T师资队伍Teachers
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副教授、硕士生导师 | |
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工学博士，博士后，副教授，硕士生导师，毕业于福州大学，研究方向聚焦疾病标志物、病原体、食品、药品等分析检测，通过利用核酸扩增分子诊断、核酸组装，光电分析纳米生物传感技术，发展了一系列检测新方法。累计共发表SCI论文60余篇（ORCID: 0000-0002-0187-2623），其中包括：第一作者和通讯作者论文40余篇（总IF＞350），中科院一区Top论文30篇，自然指数刊物6篇，研究成果发表在主流刊物Biomaterials、Analytical Chemistry、Biosensors and Bioelectronics、Journal of Hazardous Materials、Journal of Agricultural and Food Chemistry、Food Chemistry、Chemical Communication、Acs Sensors、Theranostics、Sensors & Actuators: B. Chemical，参编中英文专著2部，Journal of Analysis and Testing青年编委，授权专利1项，申请发明专利5项，参与制定行业标准和地方标注两项，获批主持国家青年基金，省基金、省重点研发计划，中国博士后基金等多项省部级项目。
食品安全危害物、疾病标志物增敏分析检测
1)国家自然科学基金青年科学基金，2019.01-2021.12，主持
2)安徽省重点研发计划项目，2020.01-2022.12，主持
3) 安徽省自然科学基金青年基金项目，2019.07-2021.06，主持
4)中国博士后科学基金面上项目，2019.06-2021.01，主持
5) 国家重点实验室开放基金项目，2019.04-2021.03，主持（经费到校）
6)集团公司学术新人提升B计划，2019.04-2020.12，主持
7)集团公司学术新人提升A计划，2018.05-2019.12，主持（结题）
8)集团公司科研启动基金，2017.06-2020.06，主持
一、期刊论文（通讯作者和第一作者）：
[1]Jianguo Xu*, Xinlei Zhang, Chao Yan, Panzhu Qin, Li Yao, Qi Wang, Wei Chen*. Trigging isothermal circular amplification-based tuning of rigorous fluorescence quenching into complete restoration on a multivalent aptamer probe enables ultrasensitive detection of Salmonella. Analytical Chemistry. 2022, 94, 2, 1357-1364
[2]Engineered G-quadruplex-embedded self-quenching probes regulate single probe-based multiplex isothermal amplification to light road lamp probes for sensitized determination of microRNAs. Jie Wang Jie, Jiayin Sun, Jing Zhang, Chenlin Shen*, Xinlei Zhang, Jianguo Xu*. Analytical Chemistry, 2022, 94, 10, 4437-4445
[3]Yinhuan Wu, Zhen Zeng, Ting Zhang, Chengxin Liu, Jianguo Xu*, Ruijie Deng, Qi Wang, and Feng Lin*. Synergetic dual-toehold mediated controllable transcription amplification for detecting lung cancer-related circulating miRNAs in blood. Sensors & Actuators: B. Chemical, 2022, 354, 131244
[4]Qi Wang #, Wenyong Li #, Juan Xia, Hai Wu, Lijun Wu*, Jianguo Xu*. Stepwise tuning of a molecular beacon coupled Y probe regulates ternary DNA nanomachine-based microRNA determination. Sensors & Actuators: B. Chemical, 2022, 363, 131858
[5]Xinlei Zhang, Jianguo Xu*, Xiuguang Xing, Li Yao, Huijie Shang, Wei Chen*. Framework nucleic acid-wrapped protein-inorganic hybrid nanoflowers with three-stage amplified fluorescence polarization for terminal deoxynucleotidyl transferase activity biosensing. Biosensors and Bioelectronics, 2021, 193: 113564
[6]Xiaoming Ma, Zhen Wang, Xuan Hu, Jinghua Chen, Huifang Zhang, Xun Li, Fengyan Xie, Jianguo Xu*. Nanozyme catalysis-powered portable mini-drainage device enables realtime and universal weighing analysis of silver ions and silver nanoparticles. Journal of Hazardous Materials, 2021, 415, 125689.
[7]Xiuguang Xing, Li Yao, Chao Yan, Zhenlin Xu, Jianguo Xu*, Guodong Liu*, Bangben Yao*, and Wei Chen*. Recent progress of personal glucose meters integrated methods in food safety hazards detection. Critical Reviews in Food Science and Nutrition. 2021: 1-14.
[8]Jianguo Xu*, Zhi Li, Yumei Li, Yusheng Lu, and Jie Wang*. Activation of palindromes on a degradable modular grafting probe enables ultrasensitive detection of microRNAs. Chemical Communications, 2021, 57, 5941-5944
[9]Xinlei Zhang, Jianguo Xu*, Chao Yan, Li Yao, Huijie Shang, Wei Chen*. Short- and long-range FRET co-functionalized fluorescence quenching collapsar probe regulates amplified and accelerated detection of Salmonella. Journal of Agricultural and Food Chemistry. 2021, 69, 14294−14301
[10]Xiaoming Ma, Shan He, Huifang Zhang, Xun Li*, Jun Xue, Xiaolin Fan, Yusheng Lu, Yiting Chen, Yanjie Zhang, and Jianguo Xu*. Delayed full opening of bumped switchable molecular probe enables repeated generation of target analogues for mix-to-signaling determination of microRNAs. Sensors & Actuators: B. Chemical, 2021, 327: 128875-128881
[11]Xinxin Wang, Jianguo Xu*, Panzhu Qin, Chao Yan, Guodong Liu, Wei Chen*. Self-assembly of a polythymine embedded activatable molecular beacon for one-step quantification of terminal deoxynucleotidyl transferase activity. Analytica Chimica Acta. 2021, 1141, 127-135.
[12]Jianguo Xu*, Xinxin Wang, Xinlei Zhang, Li Yao, Panzhu Qin, Yusheng Lu, Yiting Chen,Yanjie Zhang, Yehan Yan, Wei Chen*. Periodically programmed building and collapse of DNA networks enables an ultrahigh signal amplification effect for ultrasensitive nucleic acids analysis. Analytica Chimica Acta. 2021, 1150: 338221.
[13]Hongxin Ren, Zhijuan Qian, Min Li, Chifang Peng*, Zhouping Wang, Xinlin Wei, and Jianguo Xu*. Mesoporous silica-loaded gold nanocluster with enhanced fluorescence and ratiometric fluorescent detection of thiram in foods. Microchimica Acta, 2021, 188(11): 1-9.
[14]Hongxin Ren, Minxin Mao, Min Li, Cunzheng Zhang, Chifang Peng*, Jianguo Xu*, Xinlin Wei. A Fluorescent Detection for Paraquat Based on β-CDs-Enhanced Fluorescent Gold Nanoclusters. Foods. 2021, 10(6): 1178.
[15]Jie Wang, Shuhui Li, Jianguo Xu*, Yusheng Lu, Min Lin, Chaihung Wang, Chen Zhang, Guoxing Lin, Lee Jia*. Functionalized dumbbell probe-based cascading exponential amplification DNA machine enables amplified probing of microRNAs. Chemical Communications, 2020, 56, 1681-1684
[16]Wei Chen, Jun Teng, Li Yao, Jianguo Xu*, and Guodong Liu. Selection of specific DNA aptamers for hetero-sandwich based colorimetric determination of Campylobacter jejuni in food. Journal of Agricultural and Food Chemistry. 2020, 68, 31, 8455–8461
[17]Wei Chen*, Lijun Yang, Chao Yan, Bangben Yao, Jian-feng Lu, Jianguo Xu*, and Guodong Liu*. Surface-confined building of Au@Pt-centered and multi-G-quadruplex/hemin wires-surrounded electroactive supernanostructures for ultrasensitive monitoring of morphine. ACS Sensors. 2020, 5, 8, 2644–2651
[18]Hongbo Li*, Mingbin Liu, Weihua Zhao, Jiamei Pu, Jianguo Xu*, Suqin Wang, Ruqin Yu*. Multi-channel collection of G-quadruplex transducers for amplified signaling of Pax-5 based on target-triggered split-to-intact remodeling of dual-G-rich duplex probe. Sensors & Actuators: B. Chemical, 2020, 311: 127913-127929
[19]Xiaoming Ma, Shan He, Ying Zhang, Jianguo Xu*, Huifang Zhang, Zhen Wang, Jun Xue, Xun Li,* Wenbo Yu*. Xiaolin Fan. Signal-off tuned signal-on (SF-T-SN) colorimetric immunoassay for amantadine using activity-metalmodulated peroxidase-mimicking nanozyme. Sensors & Actuators: B. Chemical, 2020, 311, 127933-127938
[20]Wei Chen*, Fen Cai, Qian Wu, Yuhan Wu, Bangben Yao, and Jianguo Xu*. Prediction, evaluation, confirmation, and elimination of mat. rix effects for lateral flow test strip based rapid and on-site detection of aflatoxin B1 in tea. Food Chemistry. 2020, 328, 127081
[21]Zhengrong Zhang, Shisheng Chen, Jianluan Ren, Fang Han, Xiaofeng Yu, Fang Tang, Feng Xue*, Wei Chen, Jielin Yang, Yuan Jiang, Hongmei Jiang, Bo Lv, Jianguo Xu*, Jianjun Dai. Facile construction of a Molecularly Imprinted Polymer based Electrochemical Sensor for the Detection of milk amyloid A. Microchimica Acta. 2020, 187, 642.
[22]Jianguo Xu#, Chao Yan#, Xinxin Wang, Bangben Yao, Jianfeng Lu, Guodong Liu*, Wei Chen*. Ingenious design of DNA concatamers and G-quadruplex wires assisted assembly of multi-branched DNA nanoarchitectures for ultrasensitive biosensing of miRNA. Analytical Chemistry, 2019, 91: 9747-9753
[23]Panzhu Qin, Li Yao, Jianguo Xu*, Guodong Liu, Wei Chen*. Smart engineering of a dual-DNA machine with a high signal-to-noise ratio for one-pot robust and sensitive miRNA signaling. Chemical Communications, 2019,55, 14367-14370
[24]Li Yao, Yulin Li, Kewen Cheng, Daodong Pan, Jianguo Xu*, Wei Chen*,*Determination of 17β-estradiol by surface-enhanced Raman spectroscopy merged with hybridization chain reaction amplification on Au@Ag core-shell nanoparticles. Microchimica Acta, 2019, 186(2): 52.
[25]Xiaoming Ma, Zhen Wang, Shan He, Jingyi Zhao, Xiaoqi Lai*, Jianguo Xu*. L-cysteine modified gold nanoparticles for tube-based fluorometric determination of mercury(II) ions. Microchimica Acta, 2019, 186(9): 632.
[26]Wei Chen, Xinni Li, Qian Wu, Li Yao, Jianguo Xu*. Rapid and easy determination of morphine in chafing dish condiments with colloidal gold labeling based lateral flow strips. Food Science and Human Wellness, 2019, 8(1): 40-45.
[27]Panzhu Qin, Dongqing Qiao, Yan Gao, Li Yao, Jianfeng Lu, Jianguo Xu*, Wei Chen*. Self-signal-on fluorescent colorimetric protocol for rapid authentication of horsemeat adulterated beef samples with functional designed probes. International Journal of Food Science & Technology, 2019, 54(5): 1752-1759.
[28]Panzhu Qin, Wei Qu, Jianguo Xu*, Dongqing Qiao, Li Yao, Feng Xue, Wei Chen*. A sensitive multiplex PCR protocol for simultaneous detection of chicken, duck, and pork in beef samples. Journal of food science and technology, 2019, 56(3): 1266-1274.
[29]Wei Chen, Chao Yan, Lin Cheng, Li Yao, Feng Xue, Jianguo Xu*. An ultrasensitive signal-on electrochemical aptasensor for ochratoxin A determination based on DNA controlled layer-by-layer assembly of dual gold nanoparticle conjugates, Biosensors and Bioelectronics, 2018,117: 845–851 (IF= 10.618，中科院一区，TOP期刊)
[30]Jianguo Xu, Tingting Zheng, Jingqing Le, Lee Jia*, Stepwise nanoassembly of a single hairpin probe and its biosensing, Talanta, 2018, 187, 272-278
[31]Jianguo Xu, Zai-Sheng Wu*, Zhenmeng Wang, Jingqing Le, Tingting Zheng, Lee Jia*. Autonomous assembly of ordered metastable DNA nanoarchitecture and in situ visualizing of intracellular microRNAs, Biomaterials, 2017, 120: 57-65
[32]Jianguo Xu, Zai-Sheng Wu*, Weiyu Shen, Jingqing Le, Tingting Zheng, Hongling Li, Lee Jia*. Programmable nanoassembly consisting of two hairpin-DNAs for p53 gene determination, Biosensors and Bioelectronics, 2017, 94: 626-631
[33]Jianguo Xu, Zai-Sheng Wu*, Yanru Chen, Tingting Zheng, Jingqing Le, Lee Jia*. Collapse of chain anadiplosis-structured DNA nanowires for highly sensitive colorimetric assay of nucleic acids, Analyst, 2017, 142: 613-620
[34]Jianguo Xu#, Tingting Zheng#, Jingqing Le, Lee Jia*, Long-stem shaped multifunctional molecular beacon for highly sensitive nucleic acids determination via intramolecular and intermolecular interactions based strand displacement amplification, Analyst, 2017, 142: 4438–4445
[35]Jianguo Xu, Zai-Sheng Wu*, Zhenmeng Wang, Hongling Li, Jingqing Le, and Lee Jia*, Two-wheel drive-based DNA nanomachine and its sensing potential for highly sensitive analysis of cancer-related gene, Biomaterials, 2016, 100: 110-117
[36]Jianguo Xu, Zai-Sheng Wu*, Hongling Li, Zhenmeng Wang, Jingqing Le, Tingting Zheng, Lee Jia*. Dual-cyclical nucleic acid strand-displacement polymerization based signal amplification system for highly sensitive determination of p53 Gene, Biosensors and Bioelectronics, 2016, 86: 1024-1030
[37]Jianguo Xu#, Jun Qian#, Hongling Li, Zai-Sheng Wu*, Weiyu Shen, Lee Jia*, Intelligent DNA machine for the ultrasensitive colorimetric detection of nucleic acids, Biosensors and Bioelectronics, 2016, 75: 41-47
[38]Jianguo Xu, Hongling Li, Zai-Sheng Wu*, Jun Qian, Chang Xue, Lee Jia*. Double-stem hairpin probe and ultrasensitive colorimetric detection of cancer-related nucleic acids, Theranostics, 2016, 6: 318-327
[39]Jianguo Xu, Haiyan Dong, Weiyu Shen, Sudan He, Hongling Li, Yusheng Lu, Zai-Sheng Wu*, Lee Jia*. New molecular beacon for p53 gene point mutation and significant potential in serving as the polymerization primer, Biosensors and Bioelectronics, 2015, 66: 504-511
[40]Jianguo Xu, Zai-Sheng Wu*, Weiyu Shen, Huo Xu, Hongling Li, Lee Jia*. Cascade DNA nanomachine and exponential amplification biosensing, Biosensors and Bioelectronics, 2015, 73: 19-25
二、 专著：
1) Jianguo Xu, Li Yao, Lin Cheng, Chao Yan, and Wei Chen*. “Development of Aptamer-Based Electrochemical Methods.” Aptamers for Analytical Applications: Affinity Acquisition and Method Design, Willey publishing, 2018: 247-271.
《食品安全学》，郑州大学出版社，编委，2019年12月
