T师资队伍Teachers
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段亚君教授是国家自然科学基金优秀青年科学基金获得者，黄山青年学者。2004年毕业于南开大学生物科学专业，获得学士学位；2009 年毕业于南开大学生物化学与分子生物学专业，获得博士学位。
近五年发表通讯或共同通讯作者论文20余篇，共同第一作者论文2篇，其中包括：在动脉粥样硬化领域权威期刊之一ATVB发表2篇论文；在经典药理学期刊British Journal of Pharmacology发表论文2篇；在经典期刊Journal of Biological Chemistry (JBC) 发表论文6篇；在Int J Cancer发表论文1篇、Biochem J发表论文2篇、BBA-Mol Basis Dis发表论文1篇、BBA-Mol Cell Biol Lipid发表论文2篇、授权发明专利1项。发现巨噬细胞泡沫化调控的新机制，防治动脉粥样硬化的新靶点，以第一或通讯作者身份发表高质量论文三十余篇。
1.主持国家自然科学基金优秀青年科学基金: 巨噬细胞在动脉粥样硬化中的作用和机制研究，2018.1-2020.12，直接经费130万元。
2.主持国家自然科学基金面上项目: MEK1/2抑制剂协同肝X受体激动剂促进动脉粥样硬化斑块稳定与消退，2016.1-2019.12，直接经费65万元。
3.另承担国际合作项目子课题、黄山青年学者、集团公司应用科技成果培育计划重点项目、优秀青年人才培育B计划等，经费约200万元。1.Zhang S, Yu M, Guo F, Yang X, Chen Y, Ma C, Li Q, Wei Z, Li X, Wang H, Hu H, Zhang Y, Kong D, Miao Q, Hu W, Hajjar DP, Zhu Y, Han J*, Duan Y*. Rosiglitazone alleviates a-naphthylisothiocyanate-induced intrahepatic cholestasis in mice – The role of circulating 15d-PGJ2 and Nogo. British Journal of Pharmacology. 2020;177(5): 1041-1060.
2.Yu M, Zhang S, Guo F, Yang X, Li Q, Wei Z, Han J, Duan Y*, Chen Y*. Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma. Cell Signalling, 2020, 65:109429.
3.Liu Y, Wei Z, Zhang Y, Ma X, Chen Y, Yu M, Ma C, Li X, Cao Y, Liu J, Han J, Yang X*, Duan Y*. Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol. J Lipid Res. 2018 Dec;59(12):2287-2296. （封面论文并被美国生物化学与分子生物学学会新闻月刊ASBM Today专题报道）
4.Liu Y, Wei Z, Ma X, Yang X, Chen Y, Sun L, Ma C, Miao QR, Hajjar DP, Han J*, Duan Y*. 25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism. J Lipid Res. 2018 Mar;59(3):439-451.
5.Ma C, Zhang W, Yang X, Liu Y, Liu L, Feng K, Zhang X, Yang S, Sun L, Yu M, Yang J, Li X, Hu W, Miao RQ, Zhu Y, Li LY, Han J*, Chen Y*, Duan Y*. Functional interplay between LXR and AMPK inhibits atherosclerosis in apoE deficient mice-A new anti-atherogenic strategy. Br J Pharmacol. 2018 May;175(9):1486-1503.
6.Zhang W, Yang X, Chen Y, Hu W, Liu L, Zhang X, Liu M, Sun L, Liu Y, Yu M, Li X, Li LY, Zhu Y, Miao QR*, Han J*, Duan Y*. Activation of hepatic Nogo-B receptor expression—A new anti-liver steatosis mechanism of statins. Biochim Biophys Acta. 2018;1863(2):177-190.
7.Sun L, Yang X, Li Q, Zeng P, Liu Y, Liu L, Chen Y, Yu M, Ma C, Li X, Li Y, Zhang R, Zhu Y, Miao QR, Han J*, Duan Y*. Activation of Adiponectin Receptor Regulates Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Inhibits Lesions in ApoE-Deficient Mice. Arterioscler Thromb Vasc Biol. 2017 Jul;37(7):1290-1300.
8.Zhang L, Chen Y, Yang X, Yang J, Cao X, Li X, Li L, Miao QR, Hajjar DP, Duan Y*, Han J*. MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition. Biochim Biophys Acta. 2016 Sep;1861(9 Pt A):1180-91.
9.Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, Li X, Li Y, Duan S, Han J*, Duan Y*. Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM. J Biol Chem. 2016 Aug 12;291(33):16977-89. （封面论文）
10.Wang Q, Sun L, Yang X, Ma X, Li Q, Chen Y, Liu Y, Zhang D, Li X, Xiang R, Wei Y, Han J*, Duan Y*. Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene in BALB/c mice. Sci Rep. 2016 Jun 2;6:27295.
11.Yang X, Zhang W, Chen Y, Li Y, Sun L, Liu Y, Liu M, Yu M, Li X, Han J*, Duan Y*. Activation of Peroxisome Proliferator-activated Receptor γ (PPARγ) and CD36 Protein Expression: THE DUAL PATHOPHYSIOLOGICAL ROLES OF PROGESTERONE. J Biol Chem. 2016 Jul 15;291(29):15108-18.
12.Li X, Cao X, Zhang X, Kang Y, Zhang W, Yu M, Ma C, Han J, Duan Y*, Chen Y*. MEK1/2 inhibitors induce interleukin-5 expression in mouse macrophages and lymphocytes. Biochem Biophys Res Commun. 2016 May 13;473(4):939-946.
13.Liu M, Zhang W, Li X, Han J, Chen Y*, Duan Y*. Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. Biochem Biophys Res Commun. 2016 Jan 15;469(3):456-62.
14.Yang X, Yao H, Chen Y, Sun L, Li Y, Ma X, Duan S, Li X, Xiang R, Han J*, Duan Y*. Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake. J Biol Chem. 2015 Sep 4;290(36):21788-99.
15.Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li X, Han J*, Duan Y*. Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy. Sci Rep. 2015 Jun 10;5:11219.
16.Liu M, Chen Y, Zhang L, Wang Q, Ma X, Li X, Xiang R, Zhu Y, Qin S, Yu Y, Jiang XC, Duan Y*, Han J*. Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II. J Biol Chem. 2015 Jun 5;290(23):14418-29.
17.Zhang W, Wang X, Hu W, Liu L, Li X, Han J, Chen Y*, Duan Y*. Co-treatment of Pitavastatin and Dexamethasone Exacerbates the High-fat Diet-induced Atherosclerosis in apoE-deficient Mice. J Cardiovasc Pharmacol. 2015 Aug;66(2):189-95.
18.Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Han J, Li X*, Duan Y*. NaoXinTong Inhibits the Development of Diabetic Retinopathy in db/db Mice. Evid Based Complement Alternat Med. 2015;2015:242517.
19.Chen Y#, Duan Y#, Yang X, Sun L, Liu M, Wang Q, Ma X, Zhang W, Li X, Hu W, Miao RQ, Xiang R, Hajjar DP, Han J. Inhibition of ERK1/2 and activation of LXR synergistically reduce atherosclerotic lesions in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):948-59.
20.Ma X, Liu Y, Wang Q, Chen Y, Liu M, Li X, Xiang R, Wei Y, Duan Y*, Han J*. Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression. Biochim Biophys Acta. 2015 May;1852(5):1038-48.
21.Ma X, Wang Q, Liu Y, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao RQ, Duan Y*, Han J*. Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production. Int J Cancer. 2015 Feb 15;136(4):771-83. （封面论文）
22.Chen Y, Liu M, Zhao T, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li G, Li X, Xiang R, Han J, Duan Y*. Danhong injection inhibits the development of atherosclerosis in both Apoe-/- and Ldlr-/- mice. J Cardiovasc Pharmacol. 2014 May;63(5):441-52.
23.Liu M, Chen Y, Yang X, Zhang L, Zhao T, Zhao B, Jia L, Zhu Y, Gao X, Zhang B, Li X, Han J, Duan Y*. Danhong Injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice. Chinese Sci Bull. 2014;59:1366-1373.
24.Wang Q, Ma X, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao R, Hajjar DP, Duan Y*, Han J*. Identification of interferon-γ as a new molecular target of liver X receptor. Biochem J. 2014 Apr 15;459(2):345-54. (Commentary: Biochemical Journal. 2014;459:e1-e3, 专评论文)
25.Jiang M, Zhang L, Ma X, Hu W, Chen Y, Yu M, Wang Q, Li X, Yin Z, Zhu Y, Gao X, Hajjar DP, Duan Y*, Han J*. Tamoxifen inhibits macrophage FABP4 expression through the combined effects of the GR and PPARγ pathways. Biochem J. 2013 Sep 15;454(3):467-77.
26.Zhang L, Jiang M, Shui Y, Chen Y, Wang Q, Hu W, Ma X, Li X, Liu X, Cao X, Liu M, Duan Y*, Han J*. DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism. Biochim Biophys Acta. 2013 Jun;1831(6):1134-45.
27.Chen Y, Duan Y*, Kang Y, Yang X, Jiang M, Zhang L, Li G, Yin Z, Hu W, Dong P, Li X, Hajjar DP, Han J*. Activation of liver X receptor induces macrophage interleukin-5 expression. J Biol Chem. 2012 Dec 21;287(52):43340-50.
28.Duan Y#, Chen Y#, Hu W, Li X, Yang X, Zhou X, Yin Z, Kong D, Yao Z, Hajjar DP, Liu L, Liu Q, Han J. Peroxisome Proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression. J Biol Chem. 2012 Jul 6;287(28):23667-77.
29.Zhang J#, Duan Y#, Wei D, Wang L, Wang H, Gu Z, Kong D. Co-electrospun fibrous scaffold-adsorbed DNA for substrate-mediated gene delivery. J Biomed Mater Res A. 2011 Jan;96(1):212-20.
30.Duan Y#, Yang C#, Zhang Z, Liu J, Zheng J, Kong D. Poly(ethylene glycol)-grafted polyethylenimine modified with G250 monoclonal antibody for tumor gene therapy. Hum Gene Ther. 2010 Feb;21(2):191-8.
31.Duan Y, Yang C, Zhang Z, Liu J, Zheng J, Xu Y, Kong D, Yu Y. Non-viral gene carrier mediated short hairpin RNA interference for inhibition of tumor cells growth. Chinese Sci Bull. 2009;54: 2947-52.
32.Duan Y, Zheng J, Han S, Wu Y, Wang Y, Li D, Kong D, Yu Y. A tumor targeted gene vector modified with G250 monoclonal antibody for gene therapy. J Control Release. 2008 Apr 21;127(2):173-9.
